to join a dynamic team and work on in vitro and in vivo biotransformation studies. In this role, you will leverage cutting-edge...
, in vitro, and in vivo testing methodologies in accordance with ISO 10993, FDA Guidance, and global regulatory requirement...
for assessment of toxicity. Design and conduct in vitro and/or in vivo investigative and mechanistic studies in collaboration...
and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline...
/MS-based bioanalytical methods to drive in vivo PK, TK, and PK/PD analysis as well as in vitro stability characterization... understanding of in vivo PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays...
and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline...
, and multiplex assessment of multiple endpoints in a single sample. Spearhead the strategic planning and execution of ex vivo..., and oligo exposure assays specifically for tissues treated ex vivo with oligonucleotides or gene therapies, with emphasis...
identification of toxicological mechanisms and establishing in vitro-in vivo correlations. Effectively communicate scientific...
formulation optimization and characterization Support in vitro/in vivo studies by producing LNPs encapsulating siRNAs...
advanced in-silico, in-vitro, and in-vivo models that influence the selection, development, and marketing of safe therapeutics...