planning with the PI and access to institutional training. Opportunities to develop advanced skills in DoE, automation... for cell-free pathways. Expression, purification and biochemical characterisation of recombinant proteins. Development...
, interdisciplinary environment alongside experts in protein biochemistry, structural biology, biophysics, virology, and advanced imaging... or membrane proteins. You will bring strong skills in computational protein design (e.g., RFdiffusion, ProteinMPNN, alphadesign...
paediatric brain tumour, ependymoma. Using a combination of cell line models, patient-derived biofluids, and advanced molecular... techniques, the project aims to profile the molecular cargo (including proteins, lipids and RNAs) of extracellular vesicles (EVs...
structural and biophysical studies of recombinant proteins in vitro;and (3) screen small molecules that enhance these... design of glue degraders targeting hard-to-drug proteins, ultimately accelerating novel cancer therapeutics for patients...
cells), synthetic cells with different inner compartments allow multiple and advanced functionalities. The building blocks... and encapsulated proteins. To do so, the student will develop methodologies for lipid vesicle formation, including bulk techniques...
, complex process by which proteins traverse the free energy landscape, thus connecting the unfolded and the folded (native... such as Alzheimer's - but predicting how proteins fold in biological environments remains a key unmet challenge. This project brings...
for real-time protein detection in complex biological systems. Cells secrete key signalling proteins such as cytokines... manufacturing and advanced bioprocessing. The aim of this project is to develop electrochemical switchable nanobody sensors...
the deadline. All modern biotechnology, basic cell biology research and many advanced medicines rely on a cold chain... (ice binding proteins) to both understand why the cells suffer post-thaw, but to also improve and scale the process...