. You will apply expertise in human cell biology, primary cell systems, iPSC technologies, and gene editing to develop robust in vitro disease... that recapitulate disease mechanisms and phenotypes. Perform and optimize primary cell culture, iPSC differentiation...
protocols for complex cellular models (e.g., primary cells, iPSC cell lines, 2D co-cultures) Develop and optimize biochemical... with advanced cellular models (i.e., primary or iPSC derived cells, with a focus in neuroscience, immunology, and cardiometabolic...
cells;mitochondrial replacement therapy (MRT);induced pluripotent stem cell (iPSC) and embryonic stem cell (ESC...
In vitro skills: Proficiency in iPSC culture, imaging microscopy, and high throughput imaging microscopy, in vitro neuronal...
with primary cells, iPSC-derived cells, or 3D in vitro models Experience designing, executing, and interpreting in vitro...
in vitro assays is preferred Experience with primary cell culture (e.g., primary neurons and iPSC-derived neurons, astrocytes...
, and iPSC lines. Candidates must have significant research technologist experience in basic bench research, a track record...
in vitro and iPSC systems to understand and resolve differences in the functional consequence of variants in both JAG1...
approaches in vivo and in vitro, including mouse models, human iPSC-derived organoid models, high-throughput ‘omics’ approaches...
in in vitro models. Perform cell culture with immortalized cell lines, iPSC-derived cells and primary cultures, and cell-based... with iPSC-derived cells with knowledge in differentiation protocols to generate iPSC-derived neurons and other CNS cell types...