: Developing and implementing advanced platforms that integrate in vitro, in vivo, human, and molecular data to generate robust.... Strategic Vision & Leadership: Defining and implementing a transformative roadmap in vitro / in vivo correlations to enable...
agar assays and in vivo xenograft experiments. Working with a team of experimental and computational biologists to analyze...
spectrometry-based proteomics, CRISPR genetic screens (in vitro and in vivo), cell biological, and mouse modeling techniques... conditions and follwing KRAS inhibition, and assess their role in tumour progression using in vivo models. The expected outcome...
, in vivo biology) to advance siRNA candidates through discovery milestones. Maintain high experimental rigor and productivity...
and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline...
and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds for the target engagement...
function and utilizing advanced histology (IHC, RNA scope) and in vivo mouse models to advance candidates toward clinical... and develop a deep understanding of complex biological systems (e.g., ABCA4 protein function). In Vivo & Surgical Techniques...
for the design and implementation of the neural interfaces, design of the experiments and performing in vivo electrophysiology...
has an established track record in the study of metabolic pathways using in vivo and ex vivo multi-omics approaches, including... computational simulations of cardiac metabolism. We combine ex vivo organ perfusion techniques with stable isotope tracers...
experiments include, but are not limited to, assessment of tumorigenesis in in vitro and in vivo systems (cell culture and in mice...