tumors. This position will primarily conduct rigorous preclinical in vivo evaluation of drugs in clinical development... compounds. The ideal candidate must have a strong background in cancer biology and significant experience with in vivo...
will join a dynamic, multi-disciplinary team and play a key role in developing and applying in vivo models to evaluate novel cancer..., and syngeneic models. Applicants are expected to develop novel in vivo models and assays to interrogate key scientific questions...
across multiple generations of mice. The work involves the use in vivo rodent models and in vitro approaches using cells lines and the...
and managing faithful disease models in vivo (e.g., genetically engineered murine models, surgically induced murine models...
and neuropeptides in coordinating the brain’s regulation of puberty and reproduction. Lab techniques include a combination of in vivo...
, execution, and interpretation of complex in vitro/ex vivo assays as well as mechanistic experimentation to advance drug...
, drug-drug interactions (DDI) and in vitro to in vivo extrapolations towards the development of clinical candidates. QTAS... guidance and in vitro to in vivo extrapolations (IVIVE) such as PBPK modeling and in-silico ADME predictions · Experience...
and in vivo assays to conduct investigation of disease biology to establish and support evolution of a robust cardiovascular... experience in cardiovascular in vitro and in vivo models Solid understanding of drug discovery and clinical development...
, and interpretation of complex in vitro/ex vivo assays and mechanistic experimentation to advance early drug discovery projects...
-based bioanalytical methods to support in vivo PK and TK studies as well as in vitro stability characterization of biologics..., Sciex OS and MassHunter is preferred. Knowledge in drug discovery and related disciplines. In-depth understanding in vivo...