for assessment of toxicity. Design and conduct in vitro and/or in vivo investigative and mechanistic studies in collaboration...
and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline...
/MS-based bioanalytical methods to drive in vivo PK, TK, and PK/PD analysis as well as in vitro stability characterization... understanding of in vivo PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays...
and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds for the target engagement...
, and multiplex assessment of multiple endpoints in a single sample. Spearhead the strategic planning and execution of ex vivo..., and oligo exposure assays specifically for tissues treated ex vivo with oligonucleotides or gene therapies, with emphasis...
identification of toxicological mechanisms and establishing in vitro-in vivo correlations. Effectively communicate scientific...
and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds for the target engagement...
with formulation development groups and provide support for activities related to formulation development, dissolution testing, in vivo...
and in vivo proof-of-concept studies to evaluate novel extrahepatic, targeted siRNA delivery platforms across multiple pipeline...
organ systems in patients in vivo. A key element of the lab’s research involves a clinical/regulatory team to facilitate...